Other Rare Tumors

Other Rare Tumors

1. A Different Kind of Problem

You have been told your cancer is "rare." That your diagnosis appears in only a few cases per million. That your hospital has never seen it before. That there is no standard protocol.

In China, nothing is truly rare. With 1.4 billion people, a cancer that is "rare" in Europe or the US is routine here. A tumor type that a Western specialist sees once a career, our teams see monthly, sometimes weekly. At Fosun Health, we do not treat rare cancers as curiosities. We treat them as the core of our daily practice.

2. The Arsenal Does Not Care About the Label

Surgery, chemotherapy, and radiation were invented for specific organs—but they do not belong to them. A radiofrequency probe that ablates a liver tumor also ablates a sarcoma in the thigh. A beam that tracks a lung nodule also tracks a recurrent salivary gland cancer in the skull base. An iodine-125 seed that irradiates a prostate bed also irradiates a chordoma in the sacrum. At Fosun Health, our cross-cancer technology platform treats the biology, not the organ name.

Platform 1: Radiosurgery Without Borders

CyberKnife M6 delivers 0.1mm precision to any solid tumor, anywhere in the body. We do not ask "what kind of cancer is it?" We ask "where is it, and can we hit it without destroying what surrounds it?"

- Recurrent nasopharyngeal carcinoma in the skull base

- Lung metastases from renal cell carcinoma

- Bone metastases from melanoma

- Spinal epidural metastases causing paralysis risk

- Mediastinal recurrence after esophagectomy

- Unresectable pancreatic neuroendocrine tumor

All treated with the same principle: converge thousands of beams on the tumor. Spare everything else. All non-invasive. All 1–5 sessions.

Platform 2: The Interventional Highway

Our interventional platform does not discriminate by organ. If a tumor has a blood supply, we can block it, poison it, or starve it. If it is accessible by needle, we can burn it, freeze it, or seed it with radiation.

Tool

What It Does

Rare Cancer Examples

TACE / D-TACE / HAIC

Block arterial supply + deliver 50–100× local chemotherapy concentration

Hepatic metastases from neuroendocrine tumors (NETs); Gastrointestinal stromal tumor (GIST) liver deposits; Uveal melanoma liver metastases

RFA / MWA / Cryoablation

Destroy tumor through a needle puncture, preserve healthy tissue

Osteoid osteoma (bone); Renal oncocytoma; Pulmonary carcinoid; Thyroid nodule ablation; Soft tissue sarcoma recurrence

odine-125 Seeds

60–180 days continuous internal radiation

Chordoma sacral recurrence; Salivary gland cancer perineural spread; Penile cancer lymph node metastasis

Tumor Hyperthermia

40–43°C sensitization for chemo/radiation

Malignant pleural mesothelioma; Desmoid tumor (aggressive fibromatosis); Any bulky tumor needing radiosensitization

Platform 3: Molecular Hunting

For cancers with no name—or cancers that have exhausted their named treatments—we turn to NGS and molecular profiling. We do not need to know where the cancer started. We need to know what drives it.

- NTRK fusion-positive solid tumors of ANY type: Larotrectinib or entrectinib—tumor-agnostic approved therapy.

- MSI-H / dMMR across all histologies: Pembrolizumab—approved for any solid tumor with this signature.

- BRAF V600E-mutated histiocytic neoplasms, sarcomas, or anaplastic thyroid cancer: Dabrafenib + trametinib.

- RET fusion-positive lung, thyroid, or salivary gland cancers: Selpercatinib or pralsetinib.

- IDH1-mutated cholangiocarcinoma or glioma: Ivosidenib.

When the label is rare, the target is what matters. And the target—plus the drug that hits it—is available here.

3. Proof by Example: Cancers We Routinely Treat That Others Rarely See

We do not list these to impress you with Latin names. We list them to show you: whatever you have, we have treated it before.

Cancer Type

What Makes It Rare

What We Do

Soft Tissue Sarcoma (STS)

>70 subtypes; few surgeons outside major centers see more than a handful

Preoperative transarterial embolization shrinks the tumor for limb-sparing surgery; postoperative CyberKnife for positive margins; targeted therapy (pazopanib, larotrectinib) for metastatic disease

Gastrointestinal Stromal Tumor (GIST)

KIT/PDGFRA-driven; imatinib-resistant mutations require second-line precision agents

Sunitinib, regorafenib, ripretinib sequencing; arterial embolization for liver metastases; ablation for small recurrences

Neuroendocrine Tumors (NETs/NECs)

Often indolent but metastatic to liver; traditional chemotherapy ineffective for well-differentiated types

SSA (somatostatin analogues) + liver-directed TACE/HAIC + PRRT (lutetium-177) for advanced disease; surgery or ablation for limited metastases

Uveal (Ocular) Melanoma

High rate of liver-only metastasis; no standard systemic therapy

Immunoembolization (via hepatic artery) + ipilimumab/nivolumab; CyberKnife for orbital recurrence; liver-directed therapies for metastatic control

Head & Neck Salivary Gland Cancers

Diverse histology (adenoid cystic, mucoepidermoid, acinic cell); surgery risks facial nerve injury

Robotic/endoscopic resection with nerve monitoring; postoperative CyberKnife for perineural spread; iodine-125 seeds for skull-base recurrence

Primary Unknown Cancer (CUP)

No identifiable origin; many hospitals refuse treatment

NGS "site-of-origin" profiling + molecular-matched therapy ( Pembrolizumab for MSI-H, larotrectinib for NTRK) + empirical platinum doublet with tumor hyperthermia radiosensitization

Pediatric Solid Tumors

Require organ-sparing, fertility-preserving, growth-sparing approaches

Organ-sparing ablation for small renal tumors; CyberKnife for brain/spinal tumors avoiding craniotomy; fertility-preserving protocols with reduced-toxicity chemotherapy

Desmoid Tumors (Aggressive Fibromatosis)

Locally invasive but non-metastasizing; traditional surgery often worsens recurrence

Tumor hyperthermia + low-dose chemotherapy (methotrexate/vinblastine) + cryoablation for painful lesions; imatinib or sorafenib for refractory cases

4. How We Work: The "No-Label" MDT

For rare cancers, there is no standard playbook. So we write one—for you.

Every rare or complex case triggers an expanded MDT that may include:

- Pathology with sub-specialty expertise: A gastrointestinal pathologist who has seen 500 GISTs. A dermatopathologist who recognizes desmoplastic melanoma by sight. A bone pathologist who distinguishes chondrosarcoma from osteosarcoma in minutes.

- Molecular tumor board: Bioinformaticians and oncologists who interpret NGS reports not as lists of mutations, but as actionable drug maps.

- Interventional radiology: Mapping arterial anatomy for embolization, regardless of whether the tumor is in the liver, pelvis, or retroperitoneum.

- Radiation oncology: Designing IMRT, VMAT, or CyberKnife plans for anatomy that does not appear in standard textbooks.

- Surgical innovation: Robotic, endoscopic, or ablative approaches that avoid the "standard incision" when the standard incision would destroy function.

The MDT convenes within 48 hours. The plan is not a protocol downloaded from a guideline. It is a consensus blueprint built for your specific tumor biology, location, and life priorities.

5. Patient Case


6. About Fosun

Fosun Oncology Center

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Led by Dr. Yang Jun, Prof. Luo Pengfei, and Prof. Chen Tao, the Fosun Oncology Center brings together more than 20 world-class medical experts, each with over a decade of extensive oncology experience. Supported by a comprehensive range of advanced therapies — including robotic surgery, precision radiotherapy, minimally invasive intervention, CAR-T cell therapy, and Tumor Treating Fields (TTFields) — the center delivers one-stop, integrated cancer care designed to make treatment more accessible, efficient, and high-quality for every patient.

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Key Highlights

- Over 60,000 annual oncology patient admissions across Fosun’s major international hospitals in 2025

More than 17,000 cumulative TACE procedures completed between 2023 and 2025 at Fosun Hospital Guangzhou alone, with international patients accounting for over 10% of total cases

- More than 1,000 successful CyberKnife treatments performed, demonstrating world-class expertise in precision radiotherapy

- A 29.3% five-year survival rate achieved for Glioblastoma Multiforme (GBM) through combined TTFields therapy, representing a significant improvement over the 4.7% baseline

Core Services

- Robotic surgery

- Precision radiotherapy

- Minimally invasive intervention

- CAR-T cell therapy

- Tumor Treating Fields (TTFields)

- Medical oncology

- PET/CT imaging

- Pulmonary nodule diagnosis

- VIP inpatient wards

- Integrated oncology clinics

- Traditional Chinese medicine for oncology

- Cancer screening and early detection

- Genetic testing and counseling

Fosun & Fosun Health

Founded in 1992, Fosun has grown over the past three decades into a global innovation-driven consumer group. In 2007, Fosun International Limited was listed on the Main Board of the Hong Kong Stock Exchange (stock code: 00656.HK). As one of the few Chinese enterprises with strong global operational and investment capabilities, Fosun has developed substantial technological expertise and innovation capacity across multiple industries.

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Established in 2010, Shanghai Fosun Health Technology is dedicated to building a world-renowned healthcare group in Asia. Today, the group operates 19 affiliated medical institutions across Foshan, Guangzhou, Shenzhen, Zhuhai, Shanghai, and other major cities, with a total of 6,600 hospital beds and 9 Internet Hospital licenses. Fosun Health ranks No. 1 among China’s private comprehensive medical groups. Its flagship institution, Fosun Foshan Chancheng Hospital, has ranked first among private hospitals in China for eight consecutive years and was honored with the 2026 Global Health Asia-Pacific “Oncological Medical Service Provider of the Year” award.

Fosun Foshan Chancheng Hospital

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As the flagship hospital of Fosun Health, Fosun Foshan Chancheng Hospital was founded in 1958. The hospital currently hosts 28 key specialty development programs, including 2 provincial-level, 13 municipal-level, and 13 district-level key specialties. Its services span 22 medical disciplines, including spinal orthopedics, traditional Chinese medicine gynecology, obstetrics and gynecology, cardiovascular medicine, clinical laboratory medicine, anesthesiology, pediatrics, critical care medicine, ultrasound medicine, rehabilitation medicine, general practice, general surgery, and urology.

The hospital is equipped with globally advanced medical technologies, including the CyberKnife system and the Da Vinci Surgical Robot. It has 1,750 approved hospital beds and a multidisciplinary team of more than 2,800 medical professionals. The hospital records nearly 3.19 million outpatient visits annually and more than 67,000 inpatient discharges each year.

Fosun Foshan Chancheng Hospital has received numerous prestigious recognitions, including:

Global Health Asia-Pacific “Traditional Chinese Medicine Hospital of the Year”

Global Health China “Hospital of the Year”

No. 1 ranking on the GAHA Top 500 Private Hospitals in China list for eight consecutive years

The hospital has also been recognized as:

A National Model Unit for Improved Medical Services

A National Drug Clinical Trial Institution (GCP)

A National Standardized Residency Training Base

Guangzhou Fosun Chancheng Hospital (Guangzhou Xinshi Hospital)

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Established in 2003, Guangzhou Fosun Chancheng Hospital specializes in cardiovascular medicine, oncology, and neurosciences. The hospital has established a National Chest Pain Center, Stroke Center, Trauma Center, and MDT Center, supporting the development of emergency medicine, obstetrics and gynecology, intensive care, anesthesiology, gastroenterology, general surgery, urology, and general practice.

The hospital operates more than 800 inpatient beds and 48 clinical and medical technology departments, supported by a team of over 880 healthcare professionals.

Guangzhou Fosun Chancheng Hospital has received several honors and industry recognitions, including:

EMBA Innovation Practice Base

Guangdong Private Medical Reform & Innovation Brand

Guangdong Private Medical Industry Pioneer Brand

Outstanding Brand Hospital for Medical Investment Contribution

If you have been told your cancer is "too rare to treat," "has no standard protocol," or "requires travel to a distant research center"—upload your pathology report, imaging, and molecular profiling results. Our Rare and Complex Cancer MDT will review your case, identify the applicable technology platforms, and deliver a preliminary cross-disciplinary treatment plan within 48 hours.

There is no such thing as a tumor we have never seen.

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